Frequency of reactive treponemal rapid test for syphilis in pregnant and postpartum women cared for at the District Hospital of San Juan Nepomuceno, Paraguay, between 2022 and 2024
DOI:
https://doi.org/10.5281/zenodo.22149862Keywords:
syphilis, infectious complications of pregnancy, mass screening, serologic tests, prenatal care, ParaguayAbstract
Introduction: Untreated maternal syphilis causes abortion, stillbirth, prematurity and congenital syphilis, preventable outcomes with prenatal screening and penicillin. In Paraguay the burden is high and local information on screening at the primary care level is scarce. The aim was to describe the frequency of reactive treponemal rapid test for syphilis among pregnant and postpartum women cared for at the District Hospital of San Juan Nepomuceno between 2022 and 2024, and its temporal distribution. Materials and methods: Observational, descriptive and retrospective study based on the facility's monthly screening records. The proportion of pregnant women with a reactive test among all screened women and the number of postpartum women with a reactive test were described using frequencies, without individual-level data. Results: 1319 pregnant women were screened (274 in 2022, from June to December; 512 in 2023; 533 in 2024). Thirty-one had a reactive test: 2.35% of the triennium, with annual proportions of 2.19%, 1.76% and 3.00%. Twenty-six reactive tests were recorded among postpartum women. The number of women cared for and of reactive cases increased over the period. Conclusions: At this district hospital about 2% of screened pregnant women had a reactive treponemal rapid test for syphilis, with a growing number of cases between 2022 and 2024. The descriptive findings from aggregated records of a single facility do not allow estimation of population incidence, confirmation of active infection or identification of associated factors; they support screening at first prenatal contact and its repetition in the third trimester and at delivery, treatment of every seroreactive pregnant woman and her partner and improved record keeping.References
Peeling RW, Mabey D, Kamb ML, Chen XS, Radolf JD, Benzaken AS. Syphilis. Nat Rev Dis Primers. 2017;3:17073. https://doi.org/10.1038/nrdp.2017.73
Kojima N, Klausner JD. An update on the global epidemiology of syphilis. Curr Epidemiol Rep. 2018;5(1):24-38. https://doi.org/10.1007/s40471-018-0138-z
Newman L, Kamb M, Hawkes S, Gomez G, Say L, Seuc A, et al. Global estimates of syphilis in pregnancy and associated adverse outcomes: analysis of multinational antenatal surveillance data. PLoS Med. 2013;10(2):e1001396. https://doi.org/10.1371/journal.pmed.1001396
Korenromp EL, Rowley J, Alonso M, Mello MB, Wijesooriya NS, Mahiané SG, et al. Global burden of maternal and congenital syphilis and associated adverse birth outcomes-estimates for 2016 and progress since 2012. PLoS One. 2019;14(2):e0211720. https://doi.org/10.1371/journal.pone.0211720
Gomez GB, Kamb ML, Newman LM, Mark J, Broutet N, Hawkes SJ. Untreated maternal syphilis and adverse outcomes of pregnancy: a systematic review and meta-analysis. Bull World Health Organ. 2013;91(3):217-26. https://doi.org/10.2471/BLT.12.107623
Blencowe H, Cousens S, Kamb M, Berman S, Lawn JE. Lives Saved Tool supplement detection and treatment of syphilis in pregnancy to reduce syphilis related stillbirths and neonatal mortality. BMC Public Health. 2011;11 Suppl 3:S9. https://doi.org/10.1186/1471-2458-11-S3-S9
Hawkes SJ, Gomez GB, Broutet N. Early antenatal care: does it make a difference to outcomes of pregnancy associated with syphilis? A systematic review and meta-analysis. PLoS One. 2013;8(2):e56713. https://doi.org/10.1371/journal.pone.0056713
Braccio S, Sharland M, Ladhani SN. Prevention and treatment of mother-to-child transmission of syphilis. Curr Opin Infect Dis. 2016;29(3):268-74. https://doi.org/10.1097/QCO.0000000000000270
Valderrama J, Zacarías F, Mazin R. Sífilis materna y sífilis congénita en América Latina: un problema grave de solución sencilla. Rev Panam Salud Publica. 2004;16(3):211-7. https://doi.org/10.1590/s1020-49892004000900012
Heath K, Alonso M, Aguilar G, Samudio T, Korenromp E, Rowley J, et al. WHO method for estimating congenital syphilis to inform surveillance and service provision, Paraguay. Bull World Health Organ. 2022;100(3):231-6. https://doi.org/10.2471/BLT.20.271569
Ovelar P, Rolón R, Rumich A, Aguilar G, Samudio T, Cusihuamán A, et al. Situación de la sífilis congénita en Paraguay utilizando datos del sistema de información perinatal (SIP Plus). Rev Inst Med Trop. 2024;19(1):10-20. https://doi.org/10.18004/imt/2024.19.1.10
Araña-Cardozo IS, Irala-González SM, Genes de Lovera LE, Fonseca-Cáceres RJ, Bogado-Oviedo MM. Incidencia y características clínicas de recién nacidos con sífilis congénita antes y durante la pandemia SARS-CoV-2 en el Hospital General Materno Infantil San Pablo. Rev Inst Med Trop. 2025;20(2):42. https://doi.org/10.18004/imt/2025.20.2.42
Pascoal LB, Carellos EVM, Tarabai BHM, Vieira CC, Rezende LG, Salgado BSF, et al. Maternal and perinatal risk factors associated with congenital syphilis. Trop Med Int Health. 2023;28(6):442-53. https://doi.org/10.1111/tmi.13881
Domingues RMSM, Leal MC. Incidência de sífilis congênita e fatores associados à transmissão vertical: dados do estudo Nascer no Brasil. Cad Saude Publica. 2016;32(6):e00082415. https://doi.org/10.1590/0102-311X00082415
Silva ÂAO, Leony LM, Souza WV, Freitas NEM, Daltro RT, Santos EF, et al. Spatiotemporal distribution analysis of syphilis in Brazil: cases of congenital and syphilis in pregnant women from 2001-2017. PLoS One. 2022;17(10):e0275731. https://doi.org/10.1371/journal.pone.0275731
Cooper JM, Sánchez PJ. Congenital syphilis. Semin Perinatol. 2018;42(3):176-84. https://doi.org/10.1053/j.semperi.2018.02.005
McDonald R, O'Callaghan K, Torrone E, Barbee L, Grey J, Jackson D, et al. Vital signs: missed opportunities for preventing congenital syphilis - United States, 2022. MMWR Morb Mortal Wkly Rep. 2023;72(46):1269-74. https://doi.org/10.15585/mmwr.mm7246e1
Trinh T, Leal AF, Mello MB, Taylor MM, Barrow R, Wi TE, et al. Syphilis management in pregnancy: a review of guideline recommendations from countries around the world. Sex Reprod Health Matters. 2019;27(1):1691897. https://doi.org/10.1080/26410397.2019.1691897
Rac MW, Revell PA, Eppes CS. Syphilis during pregnancy: a preventable threat to maternal-fetal health. Am J Obstet Gynecol. 2017;216(4):352-63. https://doi.org/10.1016/j.ajog.2016.11.1052
Harrison J, Lind P, Sawleshwarkar S, Pasupathy D, Yapa HM. Rapid systematic review of interventions to improve antenatal screening rates for syphilis, hepatitis B, and HIV in low- and middle-income countries. Int J Gynaecol Obstet. 2024;166(1):3-26. https://doi.org/10.1002/ijgo.15425
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Copyright (c) 2025 Leandro Travisani, Ana Laura Pifer, Stefania Maria Klimczuk, Dayssy Franco (Autor/a)

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