Determinantes sistémicos y estrategias multifacéticas para la adherencia al tratamiento antihipertensivo: Una revisión integrativa (2019-2025)

Autores/as

  • Maria Eduarda Wiegert da Costa Facultad de Ciencias Médicas, Universidad Privada del Este, filial Ciudad del Este, Paraguay Autor/a
  • Maiza Vitória Aguiar Silva Oliveira Facultad de Ciencias Médicas, Universidad Privada del Este, filial Ciudad del Este, Paraguay Autor/a
  • Cecília Batista de Queiroz Facultad de Ciencias Médicas, Universidad Privada del Este, filial Ciudad del Este, Paraguay Autor/a
  • Willian Michel Wermeier Facultad de Ciencias Médicas, Universidad Privada del Este, filial Ciudad del Este, Paraguay Autor/a
  • Maria Fernanda de Abreu da Silva Facultad de Ciencias Médicas, Universidad Privada del Este, filial Ciudad del Este, Paraguay Autor/a
  • Isabella Attisano Morato Facultad de Ciencias Médicas, Universidad Privada del Este, filial Ciudad del Este, Paraguay Autor/a
  • Aurilene Coccia Prudencio Facultad de Ciencias Médicas, Universidad Privada del Este, filial Ciudad del Este, Paraguay Autor/a
  • Diana de Faria Goldin Facultad de Ciencias Médicas, Universidad Privada del Este, filial Ciudad del Este, Paraguay Autor/a
  • Andrea Paola Britos Gómez Facultad de Ciencias Médicas, Universidad Privada del Este, filial Ciudad del Este, Paraguay Autor/a https://orcid.org/0009-0000-8655-9881

Palabras clave:

Hipertensión, Cumplimiento de la medicación, Inercia terapéutica, Telemedicina, Determinantes sociales de la salud

Resumen

Introducción: La hipertensión arterial sigue siendo el principal factor de riesgo modificable para enfermedad cardiovascular global. A pesar de la eficacia farmacológica, el control de la presión arterial es subóptimo debido a la falta de adherencia a la medicación. Esta revisión integrativa analiza los determinantes críticos de la no adherencia y evalúa la eficacia de estrategias de intervención emergentes.

Métodos: Se realizó una revisión integrativa bajo la metodología de Whittemore y Knafl. Se llevaron a cabo búsquedas en PubMed/MEDLINE y Scopus (2019-2025) para identificar estudios en adultos con hipertensión esencial. Se incluyeron investigaciones sobre barreras socioeconómicas, inercia terapéutica y factores psicosociales, así como intervenciones conductuales, tecnológicas (mHealth) y farmacológicas (polypill).

Resultados: La síntesis temática revela que la no adherencia está condicionada por barreras estructurales (costos, acceso rural), baja alfabetización en salud y factores psicosociales (depresión, aislamiento social). La inercia terapéutica del proveedor exacerba el descontrol tensional. Las estrategias más efectivas incluyen la simplificación del régimen mediante combinaciones a dosis fija (polypill), el uso de salud móvil (recordatorios SMS, telemonitoreo) para aumentar la autoeficacia, y el apoyo farmacéutico y familiar. Estas intervenciones se asociaron con reducciones de la presión arterial sistólica entre -3.9 y -6.1 mmHg y una disminución en hospitalizaciones.

Conclusiones: La adherencia es un fenómeno complejo que trasciende la conducta del paciente. Mejorar los desenlaces cardiovasculares requiere transitar desde un modelo prescriptivo hacia un abordaje colaborativo que integre tecnologías de monitoreo, simplificación terapéutica y soporte psicosocial para mitigar las barreras sistémicas.

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Referencias

Mills KT, Bundy JD, Kelly TN, Reed JE, Kearney PM, Reynolds K, et al. Global disparities of hypertension prevalence and control: A systematic analysis of population-based studies from 90 countries. Circulation. 2016;134(6):441-50. doi: 10.1161/circulationaha.115.018912

Zhou B, Perel P, Mensah GA, Ezzati M. Global epidemiology, health burden and effective interventions for elevated blood pressure and hypertension. Nat Rev Cardiol. 2021;18(11):785-802. doi: 10.1038/s41569-021-00559-8

Ali DH, Kiliç B. Hart HE, Bots ML, Biermans MCJ, Spiering W, et al. Therapeutic inertia in the management of hypertension in primary care. J Hypertens. 2021;39(6):1238-45. doi: 10.1097/hjh.0000000000002783

Kankeu HT, Saksena P, Xu K, Evans DB. The financial burden from non-communicable diseases in low- and middle-income countries: a literature review. Health Res Policy Syst. 2013;11(1):31. doi: 10.1186/1478-4505-11-31

Noreen N, Bashir F, Khan AW, Safi MM, Lashari WA, Hering D. Determinants of adherence to antihypertension medications among patients at a tertiary care hospital in Islamabad, Pakistan, 2019. Prev Chronic Dis. 2023;20:E42. doi: 10.5888/pcd20.220231

Eriksson M, Carlberg B, Pennlert J, Söderberg S, Eliasson M. Time trends and socioeconomic differences in blood pressure levels: The Northern Sweden MONICA study 1994-2014. Eur J Prev Cardiol. 2017 24(14):1473-81. doi: 10.1177/2047487317722263

Tomasino C, Tomasino M. Medication adherence and non-adherence in arterial hypertension: a narrative review. Explor Med. 2025;(1001276). doi: 10.37349/emed.2025.1001276

Frimpong F, Peprah C, Owusu-Addo E, Essaw E, Asante HA. Socioeconomic determinants and barriers to accessing newly commissioned district hospitals in Ghana's Ashanti Region: An accessibility dimensions perspective. Research Square. 2025. doi: 10.21203/rs.3.rs-7503566/v1

Xu J, Zhao M, Vrosgou A, Yu NCW, Liu C, Zhang H, et al. Barriers to medication adherence in a rural-urban dual economy: a multi-stakeholder qualitative study. BMC Health Serv Res. 2021;21(1):799. doi: 10.1186/s12913-021-06789-3

Escobar C, Barrios V, Alonso-Moreno FJ, Prieto MA, Valls F, Calderon A, et al. Evolution of therapy inertia in primary care setting in Spain during 2002-2010. J Hypertens. 2014;32(5):1138-45. doi: 10.1097/hjh.0000000000000118

Wan KS, Moy FM, Mohd Yusoff MF, Mustapha F, Ismail M, Mat Rifin H, et al. Treatment intensification and therapeutic inertia of antihypertensive therapy among patients with type 2 diabetes and hypertension with uncontrolled blood pressure. Sci Rep. 2024;14(1):12625. doi: 10.1038/s41598-024-63617-4

Abdisa L, Letta S, Nigussie K. Depression and anxiety among people with hypertension on follow-up in Eastern Ethiopia: A multi-center cross-sectional study. Front Psychiatry. 2022;13:853551. doi: 10.3389/fpsyt.2022.853551

Choi J, Son G, Kim YS, Choi KH, Kim J, Park S. Impact of depression, anxiety, and COVID-19 diagnosis on social isolation trajectories during the pandemic: A 3-year prospective cohort study. PLoS One. 2025;20(9):e0330118. doi: 10.1371/journal.pone.0330118

Shen Z, Shi S, Ding S, Zhong Z. Mediating effect of self-efficacy on the relationship between medication literacy and medication adherence among patients with hypertension. Front Pharmacol. 2020;11:569092. doi: 10.3389/fphar.2020.569092

Shi S, Shen Z, Duan Y, Ding S, Zhong Z. Association between medication literacy and medication adherence among patients with hypertension. Front Pharmacol. 2019;10:822. doi: 10.3389/fphar.2019.00822

Josiah Willock R, Miller JB, Mohyi M, Abuzaanona A, Muminovic M, Levy PD. Therapeutic inertia and treatment intensification. Curr Hypertens Rep. 2018;20(1):4. doi: 10.1007/s11906-018-0802-1

Krousel-Wood M, Islam T, Muntner P, Holt E, Joyce C, Morisky DE, et al. Association of depression with antihypertensive medication adherence in older adults: cross-sectional and longitudinal findings from COSMO. Ann Behav Med. 2010;40(3):248-57. doi: 10.1007/s12160-010-9217-1

Liu P, Lyndon A, Holl JL, Johnson J, Bilimoria KY, Stey AM. Barriers and facilitators to interdisciplinary communication during consultations: a qualitative study. BMJ Open. 2021;11(9):e046111. doi: 10.1136/bmjopen-2020-046111

Yu B, Steptoe A, Chen LJ, Chen YH, Lin CH, Ku PW. Social isolation, loneliness, and all-cause mortality in patients with cardiovascular disease: A 10-year follow-up study. Psychosom Med. 2020;82(2):208-14. doi: 10.1097/psy.0000000000000777

Aubeeluck E, Al-Arkee S, Finlay K, Jalal Z. The impact of pharmacy care and motivational interviewing on improving medication adherence in patients with cardiovascular diseases: A systematic review of randomised controlled trials. Int J Clin Pract. 2021;75(11):e14457. doi: 10.1111/ijcp.14457

Xu AXT, Brown K, Schwartz KL, Aghlmandi S, Alderson S, Brehaut JC, et al. Audit and feedback interventions for antibiotic prescribing in primary care: A systematic review and meta-analysis. Clin Infect Dis. 2025;80(2):253-62. doi: 10.1093/cid/ciae604

Khanal MK, Bhandari P, Dhungana RR, Bhandari P, Rawal LB, Gurung Y, et al. Effectiveness of community-based health education and home support program to reduce blood pressure among patients with uncontrolled hypertension in Nepal: A cluster-randomized trial. PLoS One. 2021;16(10):e0258406. doi: 10.1371/journal.pone.0258406

Manalili K, Lorenzetti DL, Egunsola O, O'Beirne M, Hemmelgarn B, Scott CM, et al. The effectiveness of person-centred quality improvement strategies on the management and control of hypertension in primary care: A systematic review and meta-analysis. J Eval Clin Pract. 2022;28(2):260-77. doi: 10.1111/jep.13618

Alkhamsan AHW, Al khamsan AHY, Zabarah MM, Alyami AH, Qutayshan AMH, Aldhuwayin MHA, et al. Pharmacist-led interventions for reducing polypharmacy and improving patient outcomes: A systematic review. JoE. 2024;3(8). doi: 10.62754/joe.v3i8.4773

Buis LR, Roberson DN, Kadri R, Rockey NG, Plegue MA, Danak SU, et al. Understanding the feasibility, acceptability, and efficacy of a clinical pharmacist-led mobile approach (BPTrack) to hypertension management: Mixed methods pilot study. J Med Internet Res. 2020;22(8):e19882. doi: 10.2196/19882

Prihanti GS, Sari NP, Septiani NI, Tobing LPRL, Adrian AR, Ayu NR, et al. The effect of counseling on the adherence of therapeutic hypertension patients. J Keperawatan. 2020;11(2):110-20. doi: 10.22219/jk.v11i2.11943

Usman S, Irwan AM, Arafat R. Family involvement in low-salt diet for hypertensive older adults. Work Older People. 2023;27(1):1-14. doi: 10.1108/wwop-05-2021-0022

Masnah C, Suharti A, Daryono D. The effectiveness of interactive media in improving compliance with medication for hypertension patients. J Aisyah J Ilmu Kesehat. 2023:8(1):359-66. doi: 10.30604/jika.v8i1.1516

Arshed M, Mahmud A, Minhat HS, Lim PY, Zakar R. Effectiveness of a multifaceted mobile health intervention (Multi-Aid-Package) in medication adherence and treatment outcomes among patients with hypertension in a low- to middle-income country: Randomized controlled trial. JMIR MHealth UHealth. 2024;12:e50248. doi: 10.2196/50248

Bobrow K, Farmer AJ, Springer D, Shanyinde M, Yu LM, Brennan T, et al. Mobile phone text messages to support treatment adherence in adults with high blood pressure (SMS-Text Adherence Support [StAR]): A single-blind, randomized trial. Circulation. 2016;133(6):592-600. doi: 10.1161/circulationaha.115.017530

Xu H, Long H. The effect of smartphone app-based interventions for patients with hypertension: Systematic review and meta-analysis. JMIR MHealth UHealth. 2020;8(10):e21759. doi: 10.2196/21759

McKinstry B, Hanley J, Wild S, Pagliari C, Paterson M, Lewis S, et al. Telemonitoring based service redesign for the management of uncontrolled hypertension: multicentre randomised controlled trial. BMJ. 2013;346: 3030. doi: 10.1136/bmj.f3030

Tucker KL, Sheppard JP, Stevens R, Bosworth HB, Bove A, Bray EP, et al. Self-monitoring of blood pressure in hypertension: A systematic review and individual patient data meta-analysis. PLoS Med. 2017;14(9):e1002389. doi: 10.1371/journal.pmed.1002389

Woodham N. Intelligent pill box to improve medical adherence in elderly with hypertension: a randomized controlled trial. Office of Academic Resources, Chulalongkorn University; 2023. doi: 10.58837/chula.the.2017.483

Zaveryachev SA, Lotnik EE, Gilavyan MA, Yusupovskaya EA, Koshechkin KA. Digital Pharmacotherapy Support for Medication Adherence. Saf Risk Pharmacother. 2023;11(4):409-22. doi: 10.30895/2312-7821-2023-11-4-409-422

Du LP, Cheng ZW, Zhang YX, Li Y, Mei D. The impact of fixed-dose combination versus free-equivalent combination therapies on adherence for hypertension: a meta-analysis. J Clin Hypertens (Greenwich). 2018;20(5):902-7. doi: 10.1111/jch.13272

O'Hagan ET, McIntyre D, Nguyen T, Chow CK. Hypertension therapy using fixed-dose polypills that contain at least three medications. Heart. 2023;109(17):1273-80. doi: 10.1136/heartjnl-2022-321496

Fenton A, Sharps P, Kverno K, RachBeisel J, Gorth M. A 12-week evidence-based education project to reduce cardiovascular and metabolic risk in adults with serious mental illness in the integrated care setting. J Am Psychiatr Nurses Assoc. 2021;27(2):134-42. doi: 10.1177/1078390320902825

Parra DI, Guevara SLR, Sánchez LZR. "Teaching:Individual" to increase adherence to therapeutic regimen in people with hypertension and type-2 diabetes: Randomized controlled trial ENURSIN. Research Square. 2019. doi: 10.21203/rs.2.18001/v1

Gehi AK, Ali S, Na B, Whooley MA. Self-reported medication adherence and cardiovascular events in patients with stable coronary heart disease: the heart and soul study. Arch Intern Med. 2007;167(16):1798-803. doi: 10.1001/archinte.167.16.1798

Kelly MS, Dacey A, Siana A, Ojeda J. Efficacy and safety of a polypill to reduce cardiovascular events: A review of clinical trials. J Cardiovasc Pharmacol. 2024;83(1):8-15. doi: 10.1097/fc.0000000000001508

Monahan M, Jowett S, Nickless A, Franssen M, Grant S, Greenfield S, et al. Cost-effectiveness of telemonitoring and self-monitoring of blood pressure for antihypertensive titration in primary care (TASMINH4). Hypertension. 2019;73(6):1231-9. doi: 10.1161/hypertensionaha.118.12415

Sokol MC, McGuigan KA, Verbrugge RR, Epstein RS. Impact of medication adherence on hospitalization risk and healthcare cost. Med Care. 2005;43(6):521-30. doi: 10.1097/01.mlr.0000163641.86870.af

Alzahrani SA, Bin Muammar MF, Bin Muammar AF, Alolah A, Almutawa M. The adoption and acceptance of mHealth interventions for self-management of hypertension among adult patients: A systematic review. Cureus. 2022;14(11):e31584. doi: 10.7759/cureus.31584

Okpechi IG, Ringrose J. Padwal R, Bello AK. Telemonitoring in hypertension management for patients with chronic kidney disease: a narrative review. Conn Health. 2023;2(1):23-38. doi: 10.20517/ch.2022.18

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Publicado

2025-12-03

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Artículos de investigación original

Cómo citar

Determinantes sistémicos y estrategias multifacéticas para la adherencia al tratamiento antihipertensivo: Una revisión integrativa (2019-2025). (2025). Revista UniNorte De Medicina Y Ciencias De La Salud, 13(3), 58–68. https://revistas.uninorte.edu.py/index.php/medicina/article/view/137

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