Clinical, therapeutic and functional characteristics of neuropathic pain in patients seen at a specialized institute: A cross-sectional study
DOI:
https://doi.org/10.5281/zenodo.21765557Keywords:
neuropathic pain, sciatica, pregabalin, disability, ParaguayAbstract
Introduction: Neuropathic pain is a form of chronic pain associated with functional impairment, reduced quality of life and high diagnostic and therapeutic complexity. In clinical practice, presentations related to the lumbar spine and radicular pain represent an important share of conditions with a neuropathic component. Objective: To describe the sociodemographic, diagnostic, therapeutic and functional characteristics of patients with neuropathic pain seen at the Randall Institute during 2023. Materials and methods: Observational, descriptive, cross-sectional study based on clinical records. Thirty-four patients with a diagnosis of neuropathic pain were analyzed; 41 records were excluded because of incomplete information or lack of diagnostic confirmation. Sex, age, diagnoses, prescribed drugs, Oswestry Disability Index and visual analogue scale for pain were described. Results: Of 75 records reviewed, 34 met the analysis criteria. Women accounted for 62% and men for 38%. The highest concentration of cases was observed in the 61–70 and 71–80-year age groups. The most frequent diagnoses were sciatica (45%) and lumbar facet syndrome (23%). The most prescribed drugs were Prebictal (17 patients), pregabalin (12) and Xumer (7); several patients received more than one medication. Before the reported treatment, the Oswestry Disability Index showed intense disability in 45%, severe in 33% and moderate in 24%; at two months, minimal disability predominated in 68%. On the visual analogue scale for pain, 21% of patients reported 90% improvement and 9% complete improvement. Conclusions: In the analyzed sample, neuropathic pain was more frequent in women and older adults, with a predominance of lumboradicular diagnoses. Management was mainly pharmacological, especially with gabapentinoids and adjuvant analgesics. The observed improvement in functional and pain scales should be interpreted with caution because of the descriptive nature of the study and the absence of analytical comparison.
References
Colloca L, Ludman T, Bouhassira D, Baron R, Dickenson AH, Yarnitsky D, et al. Neuropathic pain. Nat Rev Dis Primers. 2017;3:17002. doi: https://doi.org/10.1038/nrdp.2017.2
van Hecke O, Austin SK, Khan RA, Smith BH, Torrance N. Neuropathic pain in the general population: a systematic review of epidemiological studies. Pain. 2014;155(4):654-662. doi: https://doi.org/10.1016/j.pain.2013.11.013
Caruso R, Ostuzzi G, Turrini G, Ballette F, Recla E, Dall'Olio R, et al. Beyond pain: can antidepressants improve depressive symptoms and quality of life in patients with neuropathic pain? A systematic review and meta-analysis. Pain. 2019;160(10):2186-2198. doi: https://doi.org/10.1097/j.pain.0000000000001622
Treede RD, Jensen TS, Campbell JN, Cruccu G, Dostrovsky JO, Griffin JW, et al. Neuropathic pain: redefinition and a grading system for clinical and research purposes. Neurology. 2008;70(18):1630-1635. doi: https://doi.org/10.1212/01.wnl.0000282763.29778.59
Gudala K, Bansal D, Vatte R, Ghai B, Schifano F, Boya C. High prevalence of neuropathic pain component in patients with low back pain: evidence from meta-analysis. Pain Physician. 2017;20(5):343-352.
Moisset X, Bouhassira D, Avez Couturier J, Alchaar H, Conradi S, Delmotte MH, et al. Pharmacological and non-pharmacological treatments for neuropathic pain: systematic review and French recommendations. Rev Neurol (Paris). 2020;176(5):325-352. doi: https://doi.org/10.1016/j.neurol.2020.01.361
National Institute for Health and Care Excellence. Neuropathic pain in adults: pharmacological management in non-specialist settings [Internet]. London: NICE; 2020 [citado 2 ago 2026]. Disponible en: https://www.nice.org.uk/guidance/cg173
Velasco MV. Dolor neuropático. Rev Med Clin Las Condes. 2014;25(4):625-634. doi: https://doi.org/10.1016/S0716-8640(14)70083-5
Fairbank JCT, Pynsent PB. The Oswestry Disability Index. Spine (Phila Pa 1976). 2000;25(22):2940-2953. doi: https://doi.org/10.1097/00007632-200011150-00017
Chiarotto A, Maxwell LJ, Terwee CB, Wells GA, Tugwell P, Ostelo RW. Roland-Morris Disability Questionnaire and Oswestry Disability Index: which has better measurement properties for measuring physical functioning in nonspecific low back pain? Systematic review and meta-analysis. Phys Ther. 2016;96(10):1620-1637. doi: https://doi.org/10.2522/ptj.20150420
Pérez C, Saldaña MT, Navarro A, Vilardaga I, Rejas J. Prevalence and characterization of neuropathic pain in a primary-care setting in Spain: a cross-sectional, multicentre, observational study. Clin Drug Investig. 2009;29(7):441-450. doi: https://doi.org/10.2165/00044011-200929070-00002
Mick G, Serpell M, Baron R, Mayoral V, Hans G, Mendez I, et al. Localised neuropathic pain in the primary care setting: a cross-sectional study of prevalence, clinical characteristics, treatment patterns, quality of life and sleep performance. Curr Med Res Opin. 2021;37(2):293-302. doi: https://doi.org/10.1080/03007995.2020.1846174
Park S, Park JH, Jang JN, Choi SI, Song Y, Kim YU, Park S. Pulsed radiofrequency of lumbar dorsal root ganglion for lumbar radicular pain: a systematic review and meta-analysis. Pain Pract. 2024;24(5):772-785. doi: https://doi.org/10.1111/papr.13351
Shanthanna H, Chan P, McChesney J, Thabane L, Paul J. Pulsed radiofrequency treatment of the lumbar dorsal root ganglion in patients with chronic lumbar radicular pain: a randomized, placebo-controlled pilot study. J Pain Res. 2014;7:47-55. doi: https://doi.org/10.2147/JPR.S55749
Moisset X. Neuropathic pain: evidence based recommendations. Presse Med. 2024;53(2):104232. doi: https://doi.org/10.1016/j.lpm.2024.104232
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Copyright (c) 2026 Laura Ximena Fretes Oviedo, Beatriz del Rocío Quintana López (Autor/a)

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