Relationship between inhaler adherence and quality of life in COPD patients at INERAM, 2024
DOI:
https://doi.org/10.5281/zenodo.22758237Keywords:
chronic obstructive pulmonary disease, treatment adherence, quality of lifeAbstract
Introduction: COPD is characterized by persistent airflow obstruction; management seeks to improve quality of life and reduce exacerbations, and inhaler adherence is a frequent challenge. The aim was to determine the relationship between inhaler adherence and quality of life in COPD patients at INERAM.
Materials and methods: Descriptive, correlational, non-experimental quantitative study. Thirty-three patients were assessed with TAI and CAT.
Results: Age ≥60 years 70%; male 52%. TAI: good adherence 55%, intermediate 21%, poor 24%. CAT: low impact 55% (predominant category). Pearson between adherence and quality-of-life scores r = −0.003.
Conclusions: Good adherence and low quality-of-life impact predominated, with no relevant relationship between them; other factors may influence perceived quality of life more.
References
Adeloye D, Song P, Zhu Y, Campbell H, Sheikh A, Rudan I, et al. Global, regional, and national prevalence of, and risk factors for, chronic obstructive pulmonary disease (COPD) in 2019: a systematic review and modelling analysis. Lancet Respir Med. 2022;10(5):447-58. https://doi.org/10.1016/S2213-2600(21)00511-7
Safiri S, Carson-Chahhoud K, Noori M, Nejadghaderi SA, Sullman MJM, Ahmadian Heris J, et al. Burden of chronic obstructive pulmonary disease and its attributable risk factors in 204 countries and territories, 1990-2019: results from the Global Burden of Disease Study 2019. BMJ. 2022;378:e069679. https://doi.org/10.1136/bmj-2021-069679
Zhai Y, Zhu C, Zhu T, Song W, Tang Y, Jiang L, et al. Global, regional, and national burden of chronic respiratory diseases, 1990-2021 and predictions to 2035: analysis of data from the global burden of disease study 2021. Ann Med. 2025;57(1):2530225. https://doi.org/10.1080/07853890.2025.2530225
Miravitlles M, Ribera A. Understanding the impact of symptoms on the burden of COPD. Respir Res. 2017;18(1):67. https://doi.org/10.1186/s12931-017-0548-3
Jones PW, Harding G, Berry P, Wiklund I, Chen WH, Kline Leidy N. Development and first validation of the COPD Assessment Test. Eur Respir J. 2009;34(3):648-54. https://doi.org/10.1183/09031936.00102509
Plaza V, Fernández-Rodríguez C, Melero C, Cosío BG, Entrenas LM, de Llano LP, et al. Validation of the "Test of the Adherence to Inhalers" (TAI) for asthma and COPD patients. J Aerosol Med Pulm Drug Deliv. 2016;29(2):142-52. https://doi.org/10.1089/jamp.2015.1212
Plaza V. Update on questionnaires for assessing adherence to inhaler devices in respiratory patients. Curr Opin Allergy Clin Immunol. 2018;18(1):44-50. https://doi.org/10.1097/ACI.0000000000000410
Wu J, Meng W, Ma Y, Zhao Z, Xiong R, Wang J, et al. Errors and Adherence to Inhaled Medications in Chinese Adults with COPD. J Gen Intern Med. 2024;39(1):69-76. https://doi.org/10.1007/s11606-023-08378-y
Izquierdo-Condoy JS, Gualpa Álvarez F, Morales-Lapo E, Arias Calvache WD, Bermúdez Moreira J, Quinga-Chiguano KM, et al. Adherence to Inhalation Therapy Among COPD Patients: A Cross-Sectional Study in a Tertiary Hospital in Quito, Ecuador. Int J Chron Obstruct Pulmon Dis. 2025;20:399-410. https://doi.org/10.2147/COPD.S493992
Vanoverschelde A, van der Wel P, Putman B, Lahousse L. Determinants of poor inhaler technique and poor therapy adherence in obstructive lung diseases: a cross-sectional study in community pharmacies. BMJ Open Respir Res. 2021;8(1):e000823. https://doi.org/10.1136/bmjresp-2020-000823
Murillo ER, Mora JRM, Bachiller MM, Santiago LG, Braqué NN, Bravo MO. Factors associated with low adherence to inhaled therapy in patients with chronic respiratory diseases: a cross-sectional study. BMC Pulm Med. 2025;25(1):94. https://doi.org/10.1186/s12890-025-03563-7
Humenberger M, Horner A, Labek A, Kaiser B, Frechinger R, Brock C, et al. Adherence to inhaled therapy and its impact on chronic obstructive pulmonary disease (COPD). BMC Pulm Med. 2018;18(1):163. https://doi.org/10.1186/s12890-018-0724-3
Ierodiakonou D, Sifaki-Pistolla D, Kampouraki M, Poulorinakis I, Papadokostakis P, Gialamas I, et al. Adherence to inhalers and comorbidities in COPD patients. A cross-sectional primary care study from Greece. BMC Pulm Med. 2020;20(1):253. https://doi.org/10.1186/s12890-020-01296-3
Miravitlles M, Marín A, Huerta A, Carcedo D, Villacampa A, Puig-Junoy J. Estimation of the clinical and economic impact of an improvement in adherence based on the use of once-daily single-inhaler triple therapy in patients with COPD. Int J Chron Obstruct Pulmon Dis. 2020;15:1643-54. https://doi.org/10.2147/COPD.S253567
Gregoriano C, Dieterle T, Breitenstein AL, Dürr S, Baum A, Maier S, et al. Use and inhalation technique of inhaled medication in patients with asthma and COPD: data from a randomized controlled trial. Respir Res. 2018;19(1):237. https://doi.org/10.1186/s12931-018-0936-3
Sanaullah T, Khan S, Masoom A, Mandokhail ZK, Sadiqa A, Malik MI. Inhaler Use Technique in Chronic Obstructive Pulmonary Disease Patients: Errors, Practices and Barriers. Cureus. 2020;12(9):e10569. https://doi.org/10.7759/cureus.10569
Miravitlles M, Soler-Cataluña JJ, Alcázar B, Viejo JL, García-Río F. Factors affecting the selection of an inhaler device for COPD and the ideal device for different patient profiles. Results of EPOCA Delphi consensus. Pulm Pharmacol Ther. 2018;48:97-103. https://doi.org/10.1016/j.pupt.2017.10.006
Mahler DA, Halpin DMG. Personalizing Selection of Inhaled Delivery Systems in Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc. 2023;20(10):1389-96. https://doi.org/10.1513/AnnalsATS.202304-384CME
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Bianca Anahí Avalos Candia, Felipe Miguel Oviedo Frutos (Autor/a)
This work is licensed under a Creative Commons Attribution 4.0 International License.
Articles are distributed under the Creative Commons Attribution 4.0 International — CC BY 4.0 licence. Authors retain copyright and grant the journal the right of first publication. Any reuse must acknowledge authorship, cite the original source and indicate whether changes were made.
